解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::The hemagglutinin (HA), a glycoprotein on the surface of influenza A virus (IAV), initiates the virus life cycle by binding to terminal sialic acid (SA) residues on host cells. The HA gradually accumulates amino acid substitutions that allow IAV to escape immunity through a mechanism known as antigenic drift. We recen...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.01413-18
更新日期:2019-01-04 00:00:00
abstract::Drug resistance remains a major concern for human immunodeficiency virus (HIV) treatment. To date, very few resistance mutations have emerged in first-line combination therapy that includes the integrase strand transfer inhibitor (INSTI) dolutegravir (DTG). In vitro, DTG selects for several primary mutations that indu...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.01189-18
更新日期:2019-01-04 00:00:00
abstract::Influenza A virus (IAV) remains a global health concern despite the availability of a seasonal vaccine. It is difficult to predict which strains will circulate during influenza season, and therefore, it is extremely challenging to test novel vaccines in the human population. To overcome this obstacle, new vaccines mus...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.01677-18
更新日期:2018-12-10 00:00:00
abstract::HIV-1 causes a persistent infection of the immune system that is associated with chronic comorbidities. The mechanisms that underlie this inflammation are poorly understood. Emerging literature has implicated proinflammatory purinergic receptors and downstream signaling mediators in HIV-1 infection. This study probed ...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.01186-18
更新日期:2018-12-10 00:00:00
abstract::Noroviruses (NoVs) are a leading cause of gastroenteritis worldwide, yet host factors that restrict NoV replication are not well understood. Here, we use a CRISPR activation genome-wide screening to identify host genes that can inhibit murine norovirus (MNoV) replication in human cells. Our screens identified with hig...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.01324-18
更新日期:2018-12-10 00:00:00
abstract::Rotavirus is the leading global cause of diarrheal mortality for unvaccinated children under 5 years of age. The outer capsid of rotavirus virions consists of VP7 and VP4 proteins, which determine viral G and P types, respectively, and are primary targets of neutralizing antibodies. Successful vaccination depends upon...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.01476-18
更新日期:2018-12-10 00:00:00
abstract::Rift Valley fever virus (RVFV) is an arbovirus that causes disease in livestock and humans in Africa and the Middle East. While human disease is typically mild and self-limiting, some individuals develop severe manifestations, such as hepatitis, hemorrhagic fever, or encephalitis. Encephalitis occurs 2 to 3 weeks afte...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.01270-18
更新日期:2018-11-27 00:00:00
abstract::Endocytosis and endosomal trafficking regulate the proteins targeted to the plasma membrane and play essential roles in diverse cellular processes, including responses to pathogen attack. Here, we report the identification of Glycine max (soybean) endocytosis dynamin-like protein 5A (GmSDL5A) associated with purified ...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.01320-18
更新日期:2018-11-12 00:00:00
abstract::Epstein-Barr virus (EBV) is the first human virus found to encode many microRNAs. It is etiologically linked to nasopharyngeal carcinoma and EBV-associated gastric carcinoma. During the latent infection period, there are only a few EBV proteins expressed, whereas EBV microRNAs, such as the BamHI-A region rightward tra...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.01022-18
更新日期:2018-11-12 00:00:00
abstract::Vesicular stomatitis virus Indiana strain G protein (VSVind.G) is the most commonly used envelope glycoprotein to pseudotype lentiviral vectors (LV) for experimental and clinical applications. Recently, G proteins derived from other vesiculoviruses (VesG), for example, Cocal virus, have been proposed as alternative LV...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.00900-18
更新日期:2018-11-12 00:00:00
abstract::Influenza viruses and rhinoviruses are responsible for a large number of acute respiratory viral infections in human populations and are detected as copathogens within hosts. Clinical and epidemiological studies suggest that coinfection by rhinovirus and influenza virus may reduce disease severity and that they may al...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.00881-18
更新日期:2018-11-12 00:00:00
abstract::Despite differences in the pathogenesis and host range of alphaherpesviruses, many stages of their morphogenesis are thought to be conserved. Here, an ultrastructural study of bovine herpesvirus 1 (BoHV-1) envelopment revealed profiles similar to those previously found for herpes simplex virus 1 (HSV-1), with BoHV-1 c...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.01259-18
更新日期:2018-10-29 00:00:00
abstract::One hundred thirty-eight new Epstein-Barr virus (EBV) genome sequences have been determined. One hundred twenty-five of these and 116 from previous reports were combined to produce a multiple-sequence alignment of 241 EBV genomes, which we have used to analyze variation within the viral genome. The type 1/type 2 class...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.01132-18
更新日期:2018-10-29 00:00:00
abstract::Spanins are bacteriophage lysis proteins responsible for disruption of the outer membrane, the final step of Gram-negative host lysis. The absence of spanins results in a terminal phenotype of fragile spherical cells. The phage T1 employs a unimolecular spanin gp11 that has an N-terminal lipoylation signal and a C-ter...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.00380-18
更新日期:2018-10-29 00:00:00
abstract::The influenza A virus (IAV) M2 protein is a multifunctional protein with critical roles in virion entry, assembly, and budding. M2 is targeted to the apical plasma membrane of polarized epithelial cells, and the interaction of the viral proteins M2, M1, HA, and NA near glycolipid rafts in the apical plasma membrane is...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.01425-18
更新日期:2018-10-29 00:00:00
abstract::CD8+ T cells are the key cellular effectors mediating the clearance of hepatitis B virus (HBV) infections. However, early immunological events surrounding the priming of HBV-specific CD8+ T cell responses remain poorly understood. This study examined the importance of priming location and the relative contribution of ...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.00920-18
更新日期:2018-10-12 00:00:00
abstract::The capsid mRNA transcripts of human bocavirus 1 (HBoV1) can be generated by alternative splicing from the mRNA precursor transcribed from the P5 promoter. However, the alternative translation regulation mechanism of capsid mRNA transcripts is largely unknown. Here we report that the polycistronic capsid mRNA transcri...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.00443-18
更新日期:2018-10-12 00:00:00
abstract::The hepatitis B virus (HBV) capsid or core protein (Cp) can self-assemble to form an icosahedral capsid. It is now being pursued as a target for small-molecule antivirals that enhance the rate and extent of its assembly to yield empty and/or aberrant capsids. These small molecules are thus called core protein alloster...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.01082-18
更新日期:2018-09-26 00:00:00
abstract::The γ134.5 gene of herpes simplex virus 1 (HSV-1) encodes a virulence factor that promotes viral pathogenesis. Although it perturbs TANK-binding kinase 1 (TBK1) in the complex network of innate immune pathways, the underlying mechanism is obscure. Here we report that HSV-1 γ134.5 targets stimulator of interferon genes...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.01015-18
更新日期:2018-09-26 00:00:00
abstract::The complement pathway is involved in eliminating antigen immune complexes. However, the role of the C3 complement system remains largely unknown in influenza virus M2 extracellular (M2e) domain or hemagglutinin (HA) vaccine-mediated protection after vaccination. Using a C3 knockout (C3 KO) mouse model, we found that ...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.00969-18
更新日期:2018-09-26 00:00:00
abstract::Profound alterations in host cell nuclear architecture accompany the lytic phase of Epstein-Barr virus (EBV) infection. Viral replication compartments assemble, host chromatin marginalizes to the nuclear periphery, cytoplasmic poly(A)-binding protein translocates to the nucleus, and polyadenylated mRNAs are sequestere...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.01254-18
更新日期:2018-09-26 00:00:00
abstract::Type I interferons (IFNs), as major components of the innate immune system, play a vital role in host resistance to a variety of pathogens. Canonical signaling mediated by type I IFNs activates the Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway through binding to the IFN-α/β receptor ...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.01161-18
更新日期:2018-09-12 00:00:00
abstract::The nonstructural protein (NSs) of severe fever with thrombocytopenia syndrome phlebovirus (SFTSV) sequesters TANK-binding kinase 1 (TBK1) into NSs-induced cytoplasmic structures to inhibit the phosphorylation and nuclear translocation of interferon (IFN) regulatory factor 3 (IRF3) and subsequent interferon beta (IFN-...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.00706-18
更新日期:2018-09-12 00:00:00
abstract::The Zaire ebolavirus (EBOV) glycoprotein (GP) is cleaved into two subunits (GP1 and GP2) that are both required for virus attachment and entry into cells. Sequence changes in the GP have been proposed to increase pathogenesis and to alter virus growth properties. Mutations in GP acquired during EBOV tissue culture pas...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.00820-18
更新日期:2018-09-12 00:00:00
abstract::Following the initial detection of viral infection, innate immune responses trigger the induction of numerous interferon-stimulated genes (ISGs) to inhibit virus replication and dissemination. One such ISG encodes cholesterol-25-hydroxylase (CH25H), an enzyme that catalyzes the oxidation of cholesterol to form a solub...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.01047-18
更新日期:2018-08-29 00:00:00
abstract::AIDS-related human cytomegalovirus retinitis remains the leading cause of blindness among untreated HIV/AIDS patients worldwide. To study mechanisms of this disease, we used a clinically relevant animal model of murine cytomegalovirus (MCMV) retinitis with retrovirus-induced murine AIDS (MAIDS) that mimics the progres...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.00526-18
更新日期:2018-08-29 00:00:00
abstract::Misfolded alpha-synuclein (αS) may exhibit a number of characteristics similar to those of the prion protein, including the apparent ability to spread along neuroanatomical connections. The demonstration for this mechanism of spread is largely based on the intracerebral injections of preaggregated αS seeds in mice, in...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.00586-18
更新日期:2018-08-29 00:00:00
abstract::Coinfection with HIV-1 and Kaposi's sarcoma-associated herpesvirus (KSHV) often leads to AIDS-related malignancies, including Kaposi's sarcoma (KS) and primary effusion lymphoma (PEL). The interaction between HIV and KSHV plays a pivotal role in the progression of these malignancies. We have previously demonstrated th...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.00580-18
更新日期:2018-08-29 00:00:00
abstract::Herpes simplex virus (HSV) is an important human pathogen with a high worldwide seroprevalence. HSV enters epithelial cells, the primary site of infection, by a low-pH pathway. HSV glycoprotein B (gB) undergoes low pH-induced conformational changes, which are thought to drive membrane fusion. When neutralized back to ...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.01034-18
更新日期:2018-08-16 00:00:00
abstract::Under the immune pressure of cytotoxic T cells (CTLs), hepatitis B virus (HBV) evolves to accumulate mutations more likely within epitopes to evade immune detection. However, little is known about the specific patterns of the immune pressure-associated HBV mutation of T-cell epitopes and their link to disease progress...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.02120-17
更新日期:2018-08-16 00:00:00
abstract::Infections of fungi by mycoviruses are often symptomless but sometimes also fatal, as they perturb sporulation, growth, and, if applicable, virulence of the fungal host. Hypovirulence-inducing mycoviruses, therefore, represent a powerful means to defeat fungal epidemics on crop plants. Infection with Fusarium graminea...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.00326-18
更新日期:2018-08-16 00:00:00
abstract::Human cytomegalovirus (HCMV) productive replication in vitro is most often studied in fibroblasts. In vivo, fibroblasts amplify viral titers, but transmission and pathogenesis require the infection of other cell types, most notably epithelial cells. In vitro, the study of HCMV infection of epithelial cells has been al...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.00903-18
更新日期:2018-07-31 00:00:00
abstract::The development of vaccines against bluetongue, a prevalent livestock disease, has been focused on surface antigens that induce strong neutralizing antibody responses. Because of their antigenic variability, these vaccines are usually serotype restricted. We now show that a single highly conserved nonstructural protei...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.00938-18
更新日期:2018-07-31 00:00:00
abstract::During herpes simplex virus (HSV) latency, most viral genes are silenced, with the exception of one region of the genome encoding the latency-associated transcript (LAT). This long noncoding RNA was originally described as having a role in enhancing HSV-1 reactivation. However, subsequent evidence showing that the LAT...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.00812-18
更新日期:2018-07-31 00:00:00
abstract::Influenza A virus (IAV) is a highly transmissible respiratory pathogen and a major cause of morbidity and mortality around the world. Nucleoprotein (NP) is an abundant IAV protein essential for multiple steps of the viral life cycle. Our recent proteomic study of the IAV-host interaction network found that TRIM41 (tri...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.00905-18
更新日期:2018-07-31 00:00:00
abstract::Vaccine-elicited immunoglobulin G (IgG) has been shown to be important for protection against simian-human immunodeficiency virus (SHIV) infection in rhesus monkeys. However, it remains unclear whether vaccine-elicited IgA responses are beneficial or detrimental for protection. In this study, we evaluated the kinetics...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.00537-18
更新日期:2018-07-17 00:00:00
abstract::The members of Flaviviridae utilize several endocytic pathways to enter a variety of host cells. Our previous work showed that classical swine fever virus (CSFV) enters porcine kidney (PK-15) cells through a clathrin-dependent pathway that requires Rab5 and Rab7. The entry mechanism for CSFV into other cell lines rema...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.00797-18
更新日期:2018-07-17 00:00:00
abstract::Adult T-cell leukemia (ATL) is a fatal malignancy of CD4+ T cells infected with human T-cell leukemia virus type 1 (HTLV-1). ATL cells often exhibit random gross chromosomal rearrangements that are associated with the induction and improper repair of double-stranded DNA breaks (DSBs). The viral oncoprotein Tax has bee...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.00672-18
更新日期:2018-07-17 00:00:00
abstract::Despite the long-standing observation that herpes simplex virus (HSV) latency-associated transcript (LAT) promoter deletion viruses show impaired recurrence phenotypes in relevant animal models, the mechanism by which these sequences exert this phenotypic effect is unknown. We constructed and evaluated four mutant HSV...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.00642-18
更新日期:2018-06-29 00:00:00
abstract::The Us11 protein of herpes simplex virus 1 (HSV-1) is an accessory factor with multiple functions. In virus-infected cells, it inhibits double-stranded RNA-dependent protein kinase (PKR), 2',5'-oligoadenylate synthetase, RIG-I, and MDA-5. However, its precise role is incompletely defined. By screening a human cDNA lib...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.00402-18
更新日期:2018-06-29 00:00:00